In the fast-paced world of prediction markets, where blockchain meets real-world events, tools like ChatGPT are becoming game-changers. A recent tweet from DeFi expert 0xJeff showcases how feeding a screenshot of Polymarket's trending page into ChatGPT can yield ranked opportunities based on a smart combo of correctness probability and return potential. This isn't just about betting—it's about spotting mispricings in crypto-powered markets that could give traders an edge.

Polymarket, for those new to it, is a decentralized prediction market platform built on blockchain (specifically Polygon), where users bet on outcomes of events using crypto like USDC. It's like a futuristic stock market for events, from elections to sports. In the tweet, 0xJeff prompts ChatGPT with: "Ranking of Polymarket events by 'best combo' of (a) probability of being correct AND (b) return potential." The AI then processes the screenshot and spits out a list of top picks.

Let's break down the top opportunities highlighted by ChatGPT, based on the analysis:

1. Powell Out as Fed Chair in 2025? (~8% YES)

ChatGPT's take: The true probability is closer to 1-3%.
Trade suggestion: Short YES (or buy NO).
Why it's juicy: Extremely asymmetric with high confidence it won't happen, allowing you to collect ~92¢ on the dollar.
Edge: Highest-probability with a clean payout. This one's a classic in financial prediction markets, where Fed appointments are rarely shook up without major drama.

2. NYC Mayoral Election — Zohran Mamdani 86%, Cuomo 12%

ChatGPT's take: Both massively overpriced. Mamdani isn't a serious frontrunner; Cuomo's 12% is fan premium.
Trade: Short YES on both.
Why: Very strong conviction, plus chunky payoff (especially fading Mamdani at 86%).
Edge: Biggest mispricing in the screenshot. Elections like this often see hype-driven odds, perfect for contrarian plays in blockchain betting.

3. US Open Men's Winner 2025 — Sinner 49%, Alcaraz 38% (87% combined)

ChatGPT's take: Injuries, variance, Djokovic/Medvedev/field — more like 60-65% combined.
Trade: Short YES on both or build a "NO basket."
Why: Long time to resolve, but fat expected edge.
Edge: Field almost always underpriced this far out. Sports betting on Polymarket thrives on these long-term mismatches.

4. US x Venezuela Military Engagement by October (20% YES)

ChatGPT's take: Base-rate for direct U.S.-Venezuela conflict is <5%.
Trade: Short YES.
Why: Tied-up capital until October, but very high EV (expected value).
Edge: Classic geopolitical overpricing. In crypto prediction markets, global events like this draw speculative bets, inflating odds.

5. Lisa Cook Out as Fed Governor (27% by Dec 31)

ChatGPT's take: Extremely unlikely absent scandal/health. Base-rate <5%.
Trade: Short YES (esp. December bracket).
Why: Mispriced longevity of Fed appointments.
Edge: Another Fed-related bet where stability is underestimated.

6. Top Spotify Artist 2025 — Bad Bunny 65%, Taylor Swift 36% (101% combined)

ChatGPT's take: Already >100% when you add in others.
Trade: Short multiple YES, capture arbitrage.
Why: Solid structural edge, but needs careful position sizing and fees management.
Edge: Overlaps in probabilities create free money opps, common in entertainment predictions.

This approach ties into a broader trend mentioned in the quoted tweet: the "Prophet Arena," a new AI prediction benchmark testing models like GPT-5 on real events from Polymarket and Kalshi. GPT-5 leads in Brier Score (a measure of prediction accuracy) and average returns, showing AI's growing role in forecasting.

For blockchain practitioners, this is gold. Imagine applying similar AI analysis to meme token launches or DeFi yield opportunities—spotting overhyped pumps or undervalued gems. Tools like this democratize access, turning screenshots into actionable insights without needing advanced coding skills. If you're diving into prediction markets, start by experimenting with ChatGPT on Polymarket trends; it could be your co-pilot for smarter trades in the Web3 space.

As always, remember: prediction markets involve risk, and past performance isn't indicative of future results. DYOR (do your own research) before jumping in.