Hey there, meme token aficionados and blockchain buffs! If you're keeping tabs on the wild world of decentralized finance (DeFi), you probably caught DeFiLlama's recent tweet dropping some eye-opening stats. They're the go-to for transparent DeFi analytics, and their latest share spotlights the top 10 protocols raking in the most revenue over the last seven days as of September 2025. This isn't just numbers—it's a snapshot of where the action is happening in crypto, especially for those of us eyeing meme tokens and innovative launches.

For the uninitiated, revenue here refers to the fees protocols collect after deductions like user rewards or operational costs. It's a key metric showing a project's sustainability and popularity. And with meme tokens often thriving on high-volume platforms, this list has plenty of relevance for our community at Meme Insider.

Why This Revenue Ranking Matters for Meme Tokens

DeFi protocols like these are the backbone for trading, launching, and speculating on meme coins. High revenue often signals robust user activity, which can translate to more liquidity and opportunities for viral tokens. For instance, platforms with easy token launches or perpetual trading (perps) are hotspots for meme hype. DeFiLlama tracks this via their fees page, pulling data from across chains to give us this aggregated view. Let's unpack the top performers and how they tie into the meme ecosystem.

1. Hyperliquid: The Revenue Juggernaut

Topping the chart is Hyperliquid, a decentralized exchange (DEX) on its own chain, with a whopping $20.54 million in 7-day revenue. That's from 99% of fees funneled into an Assistance Fund for buying back HYPE tokens (it was 97% before August 30, 2025). Hyperliquid specializes in perpetual futures, making it a prime spot for leveraged bets on meme coins and other assets. If you're trading volatile memes, this protocol's high liquidity could be your playground—just remember, perps amplify both gains and losses.

2. Pump: Meme Launchpad Extraordinaire

Coming in hot at second is Pump, a launchpad on a single chain (likely Solana-based, given its vibe), generating $17.97 million over the week. Revenue comes from trading and token launch fees paid by users, with the protocol keeping a slim 0.05% cut. Pump.fun has become synonymous with meme coin launches, allowing anyone to create and pump tokens with minimal barriers. It's the ultimate meme factory, where hits like PEPE or DOGE successors often start. For blockchain practitioners, it's a lesson in viral marketing and community-driven value.

3. Axiom Pro: User-Friendly Trading App

Axiom Pro, a trading app on two chains, clocks in at $13.24 million. Users get a chunk of the fees, so the protocol's take-home is lower—think builder code fees collected from trades. This setup rewards active participants, which could boost meme trading volumes. If you're into seamless interfaces for swapping or leveraging memes, Axiom Pro's model emphasizes user incentives, making it a solid pick for enhancing your DeFi toolkit.

4. Aerodrome: DEX with Treasury Focus

Aerodrome, another DEX on one chain, earned $5.5 million by directing a percentage of swap fees to its treasury or token holders. Built on Base (Ethereum's layer-2), it's known for efficient swaps and liquidity pools—perfect for meme token pairs that need quick, low-cost trades. As meme coins often rely on DEX liquidity for pumps, Aerodrome's revenue reflects growing adoption in scalable ecosystems.

5. Jupiter: Derivatives Powerhouse

Jupiter, a derivatives platform on one chain, brought in $5.15 million. It collects a portion of fees, with 25% going to the treasury and JLP holders—all fees are protocol-owned. On Solana, Jupiter aggregates DEX liquidity for optimal swaps, including meme tokens. Its revenue highlights the demand for advanced trading tools, where meme traders can hedge or amplify positions without leaving the chain.

6. Phantom: Wallet with Hidden Revenue Streams

Phantom, a multi-chain wallet (five chains), generated $4.86 million from collected fees, including builder code from Hyperliquid perps. As a popular Solana wallet, Phantom is essential for meme coin hunters—storing, swapping, and interacting with dApps. Its revenue tie-in with perps shows how wallets are evolving into revenue-generating hubs, benefiting users who engage with meme-heavy ecosystems.

7. Sky: Stablecoin CDP Leader

Sky, a collateralized debt position (CDP) protocol on one chain, netted $4.75 million after subtracting savings rates and expenses. Formerly known as MakerDAO's rebrand, Sky issues stablecoins like USDS backed by collateral. For meme enthusiasts, stable liquidity is crucial for entering volatile trades without fiat ramps—think borrowing against ETH to buy the next big meme.

8. edgeX: Derivatives for Treasury Growth

edgeX, a derivatives platform on one chain, saw $4.6 million flow to its treasury and token holders. Likely a play on dYdX or similar, it focuses on perpetuals and options. Meme tokens often see wild price swings, making derivatives platforms like this ideal for speculative bets. High revenue here points to increased interest in leveraged meme trading.

9. BasedApp: Interface for Perps Trades

BasedApp, an interface on one chain, earned $4.07 million from builder code on Hyperliquid perps trades. As a frontend for advanced trading, it's simplifying access to meme perps. For devs and traders, this shows how interfaces can capture value in the stack, enhancing meme accessibility without building from scratch.

10. Pendle: Yield and Points Specialist

Rounding out the list is Pendle, a yield protocol on eight chains, with $3.68 million from 5% of yield fees, points, and 80% of trading fees. Pendle tokenizes future yields, allowing trades on interest rates—handy for meme strategies involving staking or farming. It's a more advanced tool, but for those optimizing meme holdings, it offers ways to earn on idle assets.

Key Takeaways and Meme Implications

This revenue snapshot from DeFiLlama underscores a thriving DeFi sector, with over $79 million combined in 7-day earnings from these top 10 alone. For meme token fans, platforms like Pump and Hyperliquid are direct enablers of the next viral sensation. Keep an eye on cross-chain trends and user incentives—they're driving growth. If you're building or trading, dive deeper into these protocols to stay ahead.

Curious for more? Check out the original tweet from DeFiLlama and explore their full dashboard at defillama.com. At Meme Insider, we're all about decoding these insights to help you navigate the meme token maze. What’s your take on this list—any surprises? Drop your thoughts below!